Inhibition of tumour necrosis factor and reversal of endotoxin-induced shock by U-83836E, a 'second generation' lazaroid in rats

摘要

Antioxidants can exert protective effects in endotoxic shock by either a reduction of the oxidant damage or attenuation of Tumour Necrosis Factor(TNF-α) production. Lazaroids are a family of compounds that inhibit lipoid peroxidation. Besides, they can also reduce TNF-α. U-83836E is a new lazaroid lacking the glucocorticoid ring. Aim of our study was to investigate the effect of U-83836E on TNF-α production either in vivo or in Vitro. Endotoxic shock was produced in male rats by a single intravenous (i.v.) injection of 20 mg kg~-1 Of S. Enteritidis lipopolysaccharide (LPS).