Antagonistic action of pitrazepin on human and rat GABA_A receptors

摘要

1. Pitrazepin, 3-9piperazinyl-1)-9H-dibenz (c,f) triazolo (4, 5-a) azepin is a piperazine antagonist of GABA inm a variety of electrophysiological and in vitro binding studies involving GABA and glycine Receptors. In the present study we have investigated the effects of pitrazepin, and the GABA_A Antagonist bicuculline, on membrane currents elicited by GABA in Xenopus oocytes injected with rat Cerebral cortex mRNA or cDNA_s encoding α_1β_2 or α_1 β_2γ_2s human GABA_A receptor subunits.