Decreased vascular permeability response to substance P in airways of genetically hypertensive rats

摘要

1. The inbred genetically hypertensive strain (GH) of the Otago Wistar rat possesses more sensory neurons containing the neuropeptide substance P (SP) than does its genetically related control normotensive strain. 2 As SP contributes to airway inflammation by increasing microvascular permeability, we assessed more sensory the extrasation of Evans Blue dye in trachea and main bronchus of anaesthetized GH and control normotensive strain. 2. As SP contributes to airway inflammation by increasing microvascular permeability, we assessed the extravasation of Evans Blue dye in trachea and main bronchus o anaesthetized GH and control rats, in the presence of endogenous (capsaicin-liberated) or exogenous SP.