The effects of phosphodiesterase type 4 inhibitors on tumour necrosis factor-α

Christine Brideau; Carlo Van Staden; Angela Styhler

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The effects of phosphodiesterase type 4 inhibitors on tumour necrosis factor-α

机译：磷酸二酯酶4型抑制剂对肿瘤坏死因子-α的影响

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摘要

1. The aim of this study was to assess the inhibitory activities o phosphodiesterase type 4 (PDE4) inhibitors on tumour necrosis factor-α (TNF-α) and leukotriene B_4 (LTB_4) production in a novel human whole blood assay. 2. Lipopolysaccharide (LPS) stimulation of human whole blood caused a time dependent increase in TNF-α and prostaglandin E_2 (PGE_2) plasma levels.

机译：1.这项研究的目的是评估一种新型的人类全血检测方法对4型磷酸二酯酶（PDE4）抑制剂对肿瘤坏死因子-α（TNF-α）和白三烯B_4（LTB_4）产生的抑制作用。 2.脂多糖（LPS）对人全血的刺激引起TNF-α和前列腺素E_2（PGE_2）血浆水平的时间依赖性增加。

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来源
《British Journal of Pharmacology》 |1999年第4期|p.979-988|共10页
作者
Christine Brideau; Carlo Van Staden; Angela Styhler;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
Phosphodiesterase; tumour necrosis factorα; Leukotriene B_4;

机译：磷酸二酯酶;肿瘤坏死因子α;白三烯B_4;
入库时间 2022-08-18 00:42:38

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机译：西地那非抑制海绵体血管平滑肌细胞中由尼古丁和肿瘤坏死因子-α引起的5型磷酸二酯酶的上调：由超氧化物介导。
2. Effects of n-3 Fatty Acids on Serum Interleukin-6, Tumour Necrosis Factor-α and Soluble Tumour Necrosis Factor Receptor p55 in Active Rheumatoid Arthritis [J] . T Sundrarjun, S Komindr, N Archararit, Journal of International Medical Research . 2004,第5期

机译：n-3脂肪酸对类风湿关节炎血清白细胞介素-6，肿瘤坏死因子-α和可溶性肿瘤坏死因子受体p55的影响
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4. The Effects of Pharmacological Postconditioning with a Phosphodiesterase Type 3 Inhibitor Milrinone, and a Calcium Sensitizer Levosimendan [C] . Cho Sungsam, Matsumoto Shuhei, Sumikawa Koji ASEAN Congress of Anesthesiologists . 2009

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5. The effects of sleep and tumour necrosis factor-alpha on the lymphatic system [D] . Dickstein, Jodi Beth 1999

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6. The effects of phosphodiesterase type 4 inhibitors on tumour necrosis factor-α and leukotriene B4 in a novel human whole blood assay [O] . Christine Brideau, Carlo Van Staden, Angela Styhler, 1999

机译：新型人类全血检测中磷酸二酯酶4型抑制剂对肿瘤坏死因子-α和白三烯B4的影响
7. The effects of phosphodiesterase type 4 inhibitors on tumour necrosis factor-α and leukotriene B4 in a novel human whole blood assay [O] . Brideau, Christine, Van Staden, Carlo, Styhler, Angela, 1999

机译：新型人类全血检测中磷酸二酯酶4型抑制剂对肿瘤坏死因子-α和白三烯B4的影响

The effects of phosphodiesterase type 4 inhibitors on tumour necrosis factor-α

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