Inhibitory effects of aprindine on the delayed rectifier K~+ current and the muscarinic acetylcholine receptor-operated K~+ current in guinea-pig atrial cells

摘要

1. In order to clarify the mechanisms by which the class Ib antiarrhythmic drug aprindine shows efficacy against atrial fibrillation (AF), we examined the effects of the drug on the repolarizing K~+ currents in guinea-pig atrial cells by use of patch-clamp techniques. We also evaluated the effects of aprindine on experimental AF in isolated guinea-pig hearts.