Effects of vanadium complexes with organic ligands on glucose metabolism: a comparison study in diabetic rats

摘要

1. Vanadium compounds can mimic actions of insulin through alternative signalling pathways. The effects of three organic vanadium compounds were studied in non-ketotic, streptozotcin-diabetic rats: vanadyl acetylacetonate (Vac), vanadyl 3-ethylaceylacetonate (Vet), and bis (maltolato) ox- ovanadium (VM). A simple inorganic vanadium salt, vanadyl sulphate (VS) was also studied. 2. Oral administration of the three organic vanadium compounds (125 mg vanadium element 1~-1 in drinking fluids) for up to 3 months induced a faster and larger fall in glycemia (Vac being the most potent) than VS.