Endothelium-dependent hyperpolarization in resting and depolarized mammary and coronary arteries of guinea-pigs

摘要

1. The membrane potential responses in guinea-pig coronary and mammary arteries attributable to endothelium-derived nitric oxide (NO), prostaglandin (PG) and hyperpolarizing factor (EDHF), and to exogenous No and the prostacyclin analogue, iloprost, were compared at rest and when depolarized with the thromboxane analogue, U46619.