Endothelin receptor expression and pharmacology in human saphenous Vein graft

摘要

1. We have investigated the expression and pharmacology of endothelin (ET) receptors in human aortocoronary saphenous vein grafts. 2. Subtype-selective ligands were used tod autoradiographically identify ET_A ([~125I]-PD 151242) and ET_B ([~125I]-BQ3020) receptors. In graft saphenous vein ET_A receptors predominated in the media, With few ET_B receptors identified. Neither subtype was detected in the thickened neointima.