Oral cancer-pertinent papers 2004-2006 A personal view

摘要

We aimed to analyse the clinical, histological, and immuno-histochemical prognostic factors of a large series of adenoid cystic carcinoma, using univariate and multivariate survival analyses. All patients with adenoid cystic carcinoma of the head and neck (n - 129) treated in a single hospital in Brazil between 1955 and 1977 were selected for the study. Univariate analysis showed that age over 45 years (p = 0.04), duration of complaints of < 18 months (p = 0.007), paraes-thesiae (p = 0.04), T stage (p = 0.01), N stage (p = 0.04), M stage (p < 0.001), clinical stage (p = 0.003), solid histological type (p < 0.001), presence of residual tumour (p < 0.001), and expression of p53 (p = 0.08) all correlated with a poor prognosis. In the multivariate analyses, clinical stage, solid histological subtype, and increased expression of p53 were independent significant prognostic factors; clinical stage, solid growth pattern, and expression of p53 were the most important prognostic factors in patients with adenoid cystic carcinoma of the head and neck.