A possible role of plasma aldosterone in hypotension secondary to iron-deficiency anaemia combined with zinc deficiency in rats

摘要

Patients with Fe-deficiency anaemia are often afflicted by hypotension. However, the mechanism of secondary hypotension innFe-deficiency anaemia is unknown. To investigate the pathogenesis of secondary hypotension in Fe-deficiency anaemia, we examinednthe effects of Fe deprivation on plasma aldosterone concentration and blood pressure in rats. A total of forty 4-week-old male Spra-ngue–Dawley rats were assigned into four treatment groups of ten each for the 4-week study: Fe-deficient group (FD), Zn-deficientngroup (ZD), Fe/Zn-deficient group (FZD) and control group (CON). At days 26 and 27, blood pressure was measured by the tail-cuffnmethod. Plasma aldosterone concentration was determined by ELISA. The data were analysed by Tukey’s multiple comparison test.nRats in the FZD had significantly lower mean blood pressure (P,0·01) and diastolic blood pressures (P,0·05) and plasma aldosteronenconcentration (P,0·01) compared to the CON. These results suggest that blood pressure is decreased in Fe-deficiency anaemia combinednwith Zn deficiency partly due to decreased circulating aldosterone concentrations in addition to decreased haematocrit