Propofol consumption and recovery times after bispectral index or cerebral state index guidance of anaesthesia

摘要

Background. We compared the propofol requirements and recovery times when either thenbispectral index (BIS) monitor or the cerebral state monitor (CSM) is used to guide propofolnanaesthesia.nMethods. Forty patients undergoing laparoscopic cholecystectomy were studied. All patientsnwere monitored with both monitors and were randomly allocated into two groups accordingnto the monitor used to titrate propofol administration. Propofol was administered to maintainnBIS or CSM within 40 and 60. Propofol consumption and clinical markers of recovery werenassessed after surgery.nResults. In the CSM group, the values of cerebral state index (CSI) and BIS were 47 (5) andn38 (6), respectively (P¼0.00054). In the BIS group, the values of CSI and BIS were 47 (5) andn45 (2), respectively (P¼0.15). In the BIS group, the total amount of propofol used was lowern[109 (20) mgkgn21nmin21n] than in the CSM group [130 (27) mgkgn21nmin21n](P¼0.018). Thentime to eye opening was lower in the BIS [7.2 (3.5) min] than in the CSM group [10.7 (6.6)]n(P¼0.038). There were no differences in fentanyl consumption, or in other clinical markers ofnrecovery.nConclusions. Compared with BIS, propofol anaesthesia guided with CSI resulted in 20%nhigher propofol doses. This, however, does not lead to clinically relevant differences in recov-nery times.