Die Histonvariante CenH3 reguliert die Centromeridentität Centromerbiologie

摘要

The centromere is a specialized chromatin region that functions as foundation for kinetochore formation in mitosis. As a result, it is essential for proper chromosome segregation and the maintenance of genomic integrity. The centromere is defined epigeneti cally by the presence of the histone H3 variant CenH3 that is exclusively found within centromeric chromatin. Additionally, centromeric chromatin displays unique posttranslational modifications that differ from the surrounding heterochromatin.