SYMPOSIA

摘要

In surgical interventions loss of blood is a typical complication. A common therapeutic approach is the substitution of the blood loss volume by plasma substitutes such as hydroxyethyl starch, dextran or gelatine. None of these substitutes have a sufficient oxygen transport capacity, and, therefore, therapy with blood substitutes can negatively affect the functional integrity of all tissues in general and especially those with high oxygen consumption (e.g., the myocardium). This study was designed to obtain information about the minimal hematocrit, known as critical hematocrit (cHct), which guarantees a stable and adequate oxygen tension in the myocardium. The study was performed in pigs (strain: Deutsche Landrasse) as the animal model. The animals (n = 7, female, 56.9 ± 5.7 kg, 6 months of age) were provided from a regional breeder and the experiments were licensed by the government agency of Dresden, Germany.