Transgenerational Effects of Prenatal Stress of Different Etiology

摘要

This paper considers the transgenerational effects of prenatal stress of different etiology. The impacts of stress factors on the biochemical and morphofunctional parameters of life of the mother, fetus, and offspring in the first and subsequent generations (Fl—F4) are estimated. Particular attention is paid to assessing changes in the parameters of physical development, the state of the hypothalamic—pituitary—adrenal axis, proinflammatory status, behavioral indicators, cognitive performance, and vegetative balance in the post-stress period. Contemporary concepts of possible mechanisms of transgenerational transmission of the effects of prenatal stress are considered.