A combinatorial pattern discovery approach for the prediction of membrane dipping (re-entrant) loops

摘要

Motivation: Membrane dipping loops are sections of membrane proteins that reside in the membrane but do not traverse from one side to the other, rather they enter and leave the same side of the membrane. We applied a combinatorial pattern discovery approach to sets of sequences containing at least one characterised structure described as possessing a membrane dipping loop. Discovered patterns were found to be composed of residues whose biochemical role is known to be essential for function of the protein, thus validating our approach.