Long-term administration of large doses of paracetamol impairs the reproductive competence of male rats

摘要

To evaluate the antireproductive effect of paracetamol in male rats. Methods: Male rats were orally adminis- tered daily with 500 mg/kg or 1000 mg/kg of paracetamol for 30 consecutive dasy. Their sexual behaviour and fertility were evaluated using receptive females. Results: At 2 h after treatment, sexual behaviour was not inhibited but on day 30 both doses of paracetamol caused marked impairment of libido (assessed by % mounting, % intromission and % ejaculation),sexual vigour (numer of mounts and intromissions and intromissions and copulatory efficiency) or sexual performance (intercopulatory interval).