Practical bioinstrumentation developments for AC magnetic field- mediated magnetic nanoparticle heating applications

摘要

Heat dissipation during magnetization reversal processes in magnetic nanoparticles (MNP), upon exposure to alternating magnetic fields (AMF), has been extensively studied in relation to applications in magnetic fluid hyperthermia (MFH). This current paper demonstrates the design, fabrication, and evaluation of three innovative advances in bioinstrumentation research, operating on this principle, for use as (i) a non-contact, in vitro, real-time temperature monitor; (ii) a drug release analysis system (DRAS); and (iii) a high flux density module for AMF-mediated MNP studies. The proposed DRAS is demonstrated by an AMF-mediated drug-release proof-of-principle experiment. Also, the technique described facilitates non-contact temperature measurements of specific absorption rate (SAR) as accurately as temperature measurements using a probe in contact with the sample. Numerical calculations estimating the absolute and root mean squared flux densities, and other MNPAMF studies suggest that the proposed stacked planar coil module could be employed for calorimetry.