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Spectral tagging by integrated photonic crystal resonators for highly sensitive and parallel detection in biochips

机译:集成光子晶体谐振器进行光谱标记,可在生物芯片中进行高灵敏度和并行检测

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摘要

We propose a technological approach aimed at improving biochips performances, based on an efficient spectral modeling and enhancement of markers fluorescence through the insertion of photonic crystal nanocavities (PhC-NCs) in the readout area of biochips. This strategy univocally associates a specific emission wavelength to a specific bioprobe immobilized on a nanocavity, therefore guaranteeing parallel detection of multiple elements and faster analysis time. Moreover, PhC-NCs significantly enhance the markers fluorescence, thus improving the detection sensitivity.
机译:我们提出了一种旨在改善生物芯片性能的技术方法,该方法基于有效的光谱建模和通过在生物芯片的读取区域中插入光子晶体纳米腔(PhC-NC)来增强标记荧光。该策略明确地将特定的发射波长与固定在纳米腔上的特定生物探针相关联,从而保证了多种元素的并行检测和更快的分析时间。而且,PhC-NCs显着增强了标记物的荧光,从而提高了检测灵敏度。

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  • 来源
    《Applied Physicsletters》 |2010年第11期|p.113702.1-113702.3|共3页
  • 作者单位

    Istituto Italiano di Tecnologia (IIT), Center for Bio-Molecular Nanotechnology, Via Barsanti 1, Arnesano, Lecce 73010, Italy;

    National Nanotechnology Laboratory, CNR/INFM, Scuola superiore ISUFI, Universita del Salento, 16 Via Arnesano, Lecce 73100, ItalyLaboratoire Kastler Brossel, Universite Pierre et Marie Curie, CNRS UMR 8552, Ecole Normale Superieure, 4 place Jussieu, 75252 Paris Cedex 05, France;

    National Nanotechnology Laboratory, CNR/INFM, Scuola superiore ISUFI, Universita del Salento, 16 Via Arnesano, Lecce 73100, Italy;

    Istituto Italiano di Tecnologia (IIT), Center for Bio-Molecular Nanotechnology, Via Barsanti 1, Arnesano, Lecce 73010, Italy National Nanotechnology Laboratory, CNR/INFM, Scuola superiore ISUFI, Universita del Salento, 16 Via Arnesano, Lecce 73100, Italy;

    Istituto Italiano di Tecnologia (IIT), Center for Bio-Molecular Nanotechnology, Via Barsanti 1, Arnesano, Lecce 73010, Italy;

    Istituto Italiano di Tecnologia (IIT), Center for Bio-Molecular Nanotechnology, Via Barsanti 1, Arnesano, Lecce 73010, Italy;

    Istituto Italiano di Tecnologia (IIT), Center for Bio-Molecular Nanotechnology, Via Barsanti 1, Arnesano, Lecce 73010, Italy;

    Istituto Italiano di Tecnologia (IIT), Center for Bio-Molecular Nanotechnology, Via Barsanti 1, Arnesano, Lecce 73010, Italy National Nanotechnology Laboratory, CNR/INFM, Scuola superiore ISUFI, Universita del Salento, 16 Via Arnesano, Lecce 73100, Italy;

    Istituto Italiano di Tecnologia (IIT), Center for Bio-Molecular Nanotechnology, Via Barsanti 1, Arnesano, Lecce 73010, Italy;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
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  • 正文语种 eng
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