Model-based management of cardiovascular failure: Where medicine and control systems converge

摘要

Cardiovascular disease is growing epidemically worldwide, multiplying the impact of increasingly aging populations on intensive care unit (ICU) demand. It is the leading cause of ICU admission, length of stay, mortality and, as a result, cost. Hence, there is a significant need to bring the gains in productivity enabled by automation and control systems technologies, which have arisen in so many sectors, to medicine and this field in particular. This review presents the background to the problem and the main issues arising in care from a control systems technology perspective. It then presents a vision of a more automated future with specific goals in the areas of dynamic systems modelling, system identification and control. These areas are reviewed, followed by specific recommendations for the field, where control systems expertise can be leveraged to best advantage. (C) 2019 Elsevier Ltd. All rights reserved.