Molecular Phenotyping of Thyroid Tumors Identifies a Marker Panel for Differentiated Thyroid Cancer Diagnosis

Sam M. Wiseman MD FRCSC; Adrienne Melck MD; Hamid Masoudi MD; Fariba Ghaidi MLT; Lynn Goldstein MD; Allen Gown MD; Steven J. M. Jones PhD; Obi L. Griffith PhD

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Molecular Phenotyping of Thyroid Tumors Identifies a Marker Panel for Differentiated Thyroid Cancer Diagnosis

机译：甲状腺肿瘤的分子表型鉴定为分化型甲状腺癌诊断的标志物。

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Currently, a large proportion of individuals undergo thyroidectomy as a diagnostic procedure for cancer. The objective of this work was to evaluate the molecular phenotype of differentiated thyroid cancer (DTC) and benign thyroid lesions to identify molecular markers that allow for accurate thyroid cancer diagnosis.

机译：当前，很大一部分个体接受甲状腺切除术作为癌症的诊断程序。这项工作的目的是评估分化型甲状腺癌（DTC）和甲状腺良性病变的分子表型，以鉴定能够准确诊断甲状腺癌的分子标记。

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来源
《Annals of Surgical Oncology》 |2008年第10期|2811-2826|共16页
作者
Sam M. Wiseman MD FRCSC; Adrienne Melck MD; Hamid Masoudi MD; Fariba Ghaidi MLT; Lynn Goldstein MD; Allen Gown MD; Steven J. M. Jones PhD; Obi L. Griffith PhD;
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作者单位

Department of Surgery St. Paul’s Hospital University of British Columbia C303-1081 Burrard Street Vancouver BC Canada V6Z-1Y6;

Department of Surgery St. Paul’s Hospital University of British Columbia C303-1081 Burrard Street Vancouver BC Canada V6Z-1Y6;

Department of Surgery St. Paul’s Hospital University of British Columbia C303-1081 Burrard Street Vancouver BC Canada V6Z-1Y6;

Department of Surgery St. Paul’s Hospital University of British Columbia C303-1081 Burrard Street Vancouver BC Canada V6Z-1Y6;

PhenoPath Laboratories Seattle WA USA;

Department of Pathology University of British Columbia Vancouver BC Canada;

Department of Medical Genetics British Columbia Cancer Agency Michael Smith Genome Sciences Center University of British Columbia Vancouver BC Canada;

Department of Medical Genetics British Columbia Cancer Agency Michael Smith Genome Sciences Center University of British Columbia Vancouver BC Canada;

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原文格式 PDF
正文语种 eng
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关键词
Thyroid cancer; Molecular markers; Tissue microarray; Galectin-3;

机译：甲状腺癌;分子标记;组织芯片;Galectin-3;

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专利

1. Molecular phenotyping of thyroid tumors identifies a marker panel for differentiated thyroid cancer diagnosis. [J] . Wiseman SM, Melck A, Masoudi H, Annals of surgical oncology . 2008,第10期

机译：甲状腺肿瘤的分子表型鉴定了用于分化型甲状腺癌诊断的标记物组。
2. Immunophenotyping of thyroid tumors identifies molecular markers altered during transformation of differentiated into anaplastic carcinoma. [J] . Wiseman SM, Griffith OL, Gown A, The American Journal of Surgery . 2011,第5期

机译：甲状腺肿瘤的免疫表型鉴定可以识别分化为间变性癌的转化过程中改变的分子标记。
3. Next-Generation Sequencing Identifies a Highly Accurate miRNA Panel That Distinguishes Well-Differentiated Thyroid Cancer from Benign Thyroid Nodules [J] . Mazeh Haggi, Deutch Tova, Karas Adi, Cancer epidemiology, biomarkers and prevention: A publication of the American Association for Cancer Research . 2018,第8期

机译：下一代测序识别高度准确的miRNA面板，可区分良好分化的甲状腺癌与良性甲状腺结节
4. Clinical Engineering and Clinical Dosimetry in Patients with Differentiated Thyroid Cancer Undergoing Thyroid Remnant Ablation with Radioiodine-131 [C] . M. Medvedec, D. Dodig 12th Mediterranean conference on medical and biological engineering and computing 2010 . 2010

机译：放射性碘131消融甲状腺分化型甲状腺癌患者的临床工程和临床剂量
5. The association of obesity with thyroid cancer risk and markers of thyroid function [D] . Kitahara, Cari Meinhold. 2011

机译：肥胖与甲状腺癌风险和甲状腺功能标志物的关系
6. The Importance of the 2015 American Thyroid Association Guidelines for Adults with Thyroid Nodules and Differentiated Thyroid Cancer in Minimising Overdiagnosis and Overtreatment of Thyroid Carcinoma [O] . Valeriano Leite 2018

机译：2015年美国甲状腺协会关于甲状腺结节和分化型甲状腺癌的成年人在减少甲状腺癌的过度诊断和过度治疗中的重要性
7. Next-Generation Sequencing Identifies a Highly Accurate miRNA Panel That Distinguishes Well-Differentiated Thyroid Cancer from Benign Thyroid Nodules [O] . Haggi Mazeh, Tova Deutch, Adi Karas, 2018

机译：下一代测序识别高度准确的miRNA面板，可区分良好分化的甲状腺癌与良性甲状腺结节

Molecular Phenotyping of Thyroid Tumors Identifies a Marker Panel for Differentiated Thyroid Cancer Diagnosis

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