JC human polyomavirus is associated to chromosomal instability in peripheral blood lymphocytes of Hodgkin’s lymphoma patientsn and poor clinical outcome

摘要

Background: B cells are potential sites for latency and reactivation of the human neurotropic JC polyomavirus (JCV). We investigated JCV and Epstein–Barr virus (EBV) status in peripheral blood lymphocytes (PBL) from 74 Hodgkin’s lymphoma (HL) and 91 B-cell non-Hodgkin’s lymphoma (B-NHL) patients.