Collection, Validation and Generation of Bitumen Fumes for Inhalation Studies in Rats Part 1: Workplace Samples and Validation Criteria

摘要

Objectives: Undertaking a chronic inhalation study on bitumen fume presents a challenge in terms of generating large amounts of representative fume. The objective of the study described in this and the following contributions was to collect sufficient fume and develop a laboratory-generated exposure atmosphere that resembles, as closely as possible, personal exposures seen in workers during road paving operations, for use in chronic inhalation toxicity studies in rats.