NIOSH Definition of Closed-System Drug-Transfer Devices

摘要

Following publication of our paper on a double-filter system for preparing drugs (Nygren et al., 2008), we have received some comments on the Results and discussion section, where the tested system is compared with other devices in relations to the National Institute for Occupational Safety and Health (NIOSH) definition of a closed system. nThe discussion refers to how the NIOSH definitions (NIOSH, 2004) should be interpreted and how different drug-transfer devices comply with the definition. The NIOSH definitions are as follows: nClosed system drug-transfer device (CSTD): a drug transfer device that mechanically prohibits the transfer of environmental contaminants into the system and the escape of hazardous drug or vapor concentrations outside the system. nnClosed system: a device that does not exchange unfiltered air or contaminants with the adjacent environment.