Determination of molecular-weight distribution of dextran for injection by size-exclusion chromatography and study for molecular-weight standards

摘要

It is well known that dextran for clinical use should have narrow molecular- weight(Mw) distributions, because any material with a Mw that is too small is rapidly lost from circulation, and is therefore therapeutically ineffective; also, any material with a Mw that is too high can interfere with the normal coagulation process of the blood. There- fore, accurate and rapid methods are necessary for measuring the Mw the distribution of dextran.