Neuronal biosensors using liposomal delivery of local anesthetics

摘要

The use of liposomal drug incorporation significantly improves the sensitivity of neuronal sensors to poorly soluble drugs and extends the applicability of such sen- sors to previously undetectable compounds. Data pre- sented support physiological models for liposome- neuron interactions and are consistent with the channel- blocking actions of local anesthetics. We have incorporated the anesthetics benzocaine, bupivacaine, and tetracaine into liposomes, generating dose-response curves.