Impact of Five Annual Rounds of Mass Drug Administration with Diethylcarbamazine and Albendazole on Wuchereria bancrofti Infection in American Samoa

摘要

Abstract. American Samoa began a territory-wide mass drug administration (MDA) program with diethylcarbamazinenand albendazole in 2000 after baseline surveys indicated that 16.5% of 2,989 residents were infected with Wuchererianbancrofti based on tests for circulating filarial antigen. Follow-up surveys were conducted in 2001, 2003, and 2006,nusing convenience samples of residents of sentinel villages. Antigenemia prevalence in 2001 (11.5%) and 2003 (13.5%)nshowed no change. After the 2003 sentinel assessment, improvements were made in the social mobilization and drugndistribution strategies. In 2006, after a total of 5 years of MDA and 3 years of improved MDA participation, thenantigenemia prevalence dropped from 11.5% (2001) to 0.95% (2006) (P < 0.0001). In 2006, antigenemia prevalence wasngreater in males (1.5%) than females (0.4%) (P u0001 0.04). The decline in antigenemia prevalence shows the effectivenessnof MDA and changes made in social mobilization and drug distribution.