Molecular biology took Humpty Dumpty apart; mathematical modeling is required to put him together again." This statement in our cover article, "Multi-scale Modeling in Biology," is likely to provoke both smiles and scowls from biologists. Scowlers, please note that the writers intend no criticism of the ascendant scientific subfield of our day. Un-derstanding even the smallest living unit, the cell, requires integrating information about structure and function across multiple scales of space and time. Now more than ever, experimenters (biologists) and modelers (largely mathematicians and physicists) need to talk.
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