Effects of Inter -α-inhibitor in Experimental Endotoxic Shock and Disseminated Intravascular Coagulation

摘要

We investigated the effects of human inter -α-inhibitor (|a|) on hemodynamics, oxygenation, and co - agulation parameters in a porcine model of endotoxic shock. Four groups of six animals were studied: (1) control, (2) |α| group receiving 30 mg/kg |α| over 30 min, (3) LPS group receiving 5 μg. kg/min Escherichia coli endotoxin over 30 min, and (4) LPS + |a| group receiving 30 min after endotoxin 30 mg/kg/30 min |α|.