The Role of the Hemodynamic and Clotting Properties of Blood in the Development of Disseminated Intravascular Coagulation and Shock

摘要

Disseminated intravascular coagulation, probably an essential component of shock, can only be observed adequately by intravital microscopy. The author's improvements and new developments of such methods are described. The processing of signals picked up optically from the monitor screen was improved for use with television systems (flying spot microscope, TV cameras). A new method was developed which performs optical statistics of the perfusion in a microscopic capillary area using random probes. The statistical information is analyzed by frequency power spectrum methods. This method demands less expenditure on electronics than do TV systems and the time resolution is good. Being optically very sensitive, it can be applied to reflected light microscopy without exerting thermal stress on the capillary area observed. It delivers relative values of perfusion distribution among the different types of blood vessel observed within the area. ....Endotoxin experiments were done with rat and frog epithelia. No dramatic microcirculatory changes were seen. This may be due to a peculiarity of the tissue and similar observations on rat kidney are therefore planned.... The report contains abstracts of two papers given at international conferences. (Author)