Inhibition of PAF-induced gas exchange defects by geta-adrenergic agonists in mild asthma is not due to bronchodilation

摘要

Salbutamol inhibits neutropenia, increased airway resistance, and gas exchange abnormalities pro- voked by platelet-activating factor (PAF) challenge in normal persons. To further explore the intrigu- ing dissociation between spirometric abnormalities and gas exchange defects shown in patients with asthma, we investigated whether the salbutamol-induced improvement of gas exchange distur- bances after PAF is the results of bronchodilation by comparing this effect with that of ipratropium bromide.