Combined antagonism of leukotrienes and histamine produces predominant inhibition of allergen-induced early and late phase airway obstruction in asthmatics

摘要

ew defined the contribution of histamine and leukotrienes to allergen-induced airway obstruction in asthmatics; 12 subjects with allergic asthma underwent identical allergen bonchoprovocations on four occasions. At control session, all subjects displayed early (EAR) and late asthmatic (LAR) reac- tions. The mean (±SE) drop in FEV_1 (0-2 h) and LAR (2-12 h) was 29±2/100 and 28±4/100, respectively. Thereafter, the influence of 1 wk randomized pretreatment with the leukotriene recep- tor antagonist zafirlukast (Accolate~TM) (80 mg twice daily), the antihistamine loratadine (10 mg twice daily), and the combination of both antagonists was assessed.