Pulmonary and systemic inflammatory responses in rabbits with gram-negative pneumonia

摘要

The major goals of this study were to define the relationships between intrapulmonary and systemic inflammatroy responses in animals with gram-negative pneumonia. We treated rabbits with intra- pulmonary Escherichia coli (1 x 10~7 to 1 x 10~10 cfu/ml), and then measured physiologic, cellular, and molecular events in the lungs and systemic circulation for 24 h. The treatment protocols resulted in groups of animals that mimicked the stages of the septic inflammatory response in humans.