Tnf mediates lung leak, but not neutrophil accumulation, in lungs of rats given IL-1 intratracheally

摘要

Interleukin-1 9IL-1) is increased in lung lavages obtained from patients with acute respiratory distress syndrome, and administering Il-1 intratracheally to rats causes an acute, neutrophil-dependent, oxi- dative lung leak. We found that rats given IL-1 intratracheally had increased lung lavage fluid tumor necrisis factor (TNF) levels, and that rats treated with TNF binding protein (TNFbp) intravenously did not develop the increased lung leak that occurs after administration of IL-1 intratracheally.