Nonsignificant Weight Gain With Atypical Antipsychotics in Men With Alzheimer's Disease: An Important Result of the CATIE-Alzheimer's Disease Study/Drs. Schneider, Zheng, and Mack Reply

摘要

[...] we would like to suggest that cross-cultural studies are required before definite conclusions can be made about the metabolic side effects of atypical antipsychotics in Alzheimer's disease patients. In these CATIE-AD patients, atypical antipsychotics were generally not effective in terms of all-cause discontinuation (2), although during phase I of the trial there were small salutary effects on behavioral rating scales relative to placebo (3). [...] metabolic effects should be added to the list of adverse effects of antipsychotics that pose risk and may limit their overall effectiveness in Alzheimer's disease.