Anti-Viral T-Cell Immunity + Anti-CNS Autoantibody = A Model for Human Acute Disseminated Encephalomyelitis or Multiple Sclerosis Relapse?

摘要

In this issue of The American Journal of Pathology, Burrer et al.1 report exacerbation and increased mortality in three mouse models of otherwise relatively benign viral encephalitis by the genetic introduction or passive transfer of myelin oligodendrocyte glycoprotein (MOG)-specific antibody. In mouse hepatitis virus (MHV) encephalomyelitis, enhanced central nervous system (CNS) inflammation and demyelination are attributed to anti-MOG antibody-mediated mechanisms rather than to the anti-viral T-cell response. The authors demonstrate that exacerbation of clinical disease is associated with increases in neutrophil and NK cell infiltration of the central nervous system and greater tissue damage.