Systematic Review and Meta-Analysis of the Association Between Complement Component 3 and Age-related Macular Degeneration: A HuGE Review and Meta-Analysis

摘要

The authors performed a meta-analysis to estimate the magnitude of polymorphism effects for the complementncomponent C3 gene (C3) and their possible mode of action on age-related macular degeneration (AMD). Thenmeta-analysis included 16 and 7 studies for rs2230199 and rs1047286, respectively. Data extraction and risk ofnbias assessments were performed in duplicate, and heterogeneity and publication bias were explored. There wasnmoderate evidence for association between both polymorphisms and AMD in Caucasians. For rs2230199, patientsnwith CG and GG genotypes were 1.44 (95% confidence interval (CI): 1.33, 1.56) and 1.88 (95% CI: 1.59, 2.23)ntimes more likely to have AMD than patients with the CC genotype. For rs1047286, GA and AA genotypes had 1.27n(95% CI: 1.15, 1.41) and 1.70 (95% CI: 1.27, 2.11) times higher risk of AMD than did GG genotypes. These geneneffects suggested an additive model. The population attributable risks for the GG/GC and AA/GA genotypes arenapproximately 5%–10%. Subgroup analysis by ethnicity indicates that these variants are very infrequent in Asiansnand that the observed gene effects are based largely on the high frequency within Caucasian populations. Thisnmeta-analysis supports the association between C3 and AMD and provides a robust estimate of the genetic risk.