Screening for Phenylketonuria: Reaffirmation Recommendation Statement

摘要

The sensitivity and specificity of fluorometry are 100 and 51 percent, respectively.3 The sensitivity and specificity of tandem mass spectrometry are 100 and 98 percent, respectively.3 Benefits of detection and early intervention. Sick infants and premature infants should be screened by seven days of age, regardless of feeding history or antibiotic treatment.5 The American Academy of Family Physicians strongly recommends that physicians screen neonates for PKU.6 The American College of Medical Genetics recommends that PKU screening be mandated as part of state newborn screening programs.7 This recommendation statement was first published in Ann Fam Med. 2008;6(2):166.