Role of Genotype in the Development of Locomotor Sensitization to Alcohol in Adult and Adolescent Mice: Comparison of the DBA/2J and C57BL/6J Inbred Mouse Strains

摘要

Background: Animal models that explore differential sensitivity to the effects of acute and repeated exposure of alcohol (ethanol) may be influenced by both the developmental and genetic profile of the population. Therefore, we sought to compare the influence of ontogeny on sensitivity to ethanol-induced locomotor stimulation and on the induction of locomotor sensitization to this effect across 2 inbred strains of mice; the ethanol consuming C57BL/6J and the ethanol avoiding DBA/2J strains.