Comparison of the Effect of the GABA<sub>B</sub> Receptor Agonist, Baclofen, and the Positive Allosteric Modulator of the GABA<sub>B</sub> Receptor, GS39783, on Alcohol Self-Administration in 3 Different Lines of Alcohol-Preferring Rats

Paola Maccioni; Alessandro Zaru; Barbara Loi; Carla Lobina; Mauro A. M. Carai; Gian Luigi Gessa; Alessandro Capra; Claudia Mugnaini; Serena Pasquini; Federico Corelli; Petri Hyyti; Lawrence Lumeng; Giancarlo Colombo

首页> 外文期刊>Alcoholism: Clinical and Experimental Research >Comparison of the Effect of the GABA_B Receptor Agonist, Baclofen, and the Positive Allosteric Modulator of the GABA_B Receptor, GS39783, on Alcohol Self-Administration in 3 Different Lines of Alcohol-Preferring Rats

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Comparison of the Effect of the GABA_B Receptor Agonist, Baclofen, and the Positive Allosteric Modulator of the GABA_B Receptor, GS39783, on Alcohol Self-Administration in 3 Different Lines of Alcohol-Preferring Rats

机译：比较GABA _{B 受体激动剂巴氯芬和GABA _{B 受体GS39783的正变构调节剂对3种不同品系的酒精自我给药的影响嗜酒大鼠}}

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摘要

Administration of the GABA_B receptor agonist, baclofen, and positive allosteric modulator, GS39783, has been repeatedly reported to suppress multiple alcohol-related behaviors, including operant oral alcohol self-administration, in rats. This study was designed to compare the effect of baclofen and GS39783 on alcohol self-administration in 3 lines of selectively bred, alcohol-preferring rats: Indiana alcohol-preferring (P), Sardinian alcohol-preferring (sP), and Alko Alcohol (AA).

机译：GABA _{B 受体激动剂巴氯芬和正变构调节剂GS39783的给药已被反复报道，以抑制大鼠多种与酒精有关的行为，包括自行口服口服酒精。这项研究旨在比较巴氯芬和GS39783在3种选择性繁殖，偏爱酒精的大鼠中对酒精自我给药的影响：印第安纳偏爱酒精（P），撒丁岛偏爱酒精（sP）和Alko Alcohol（AA））。}

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来源
《Alcoholism: Clinical and Experimental Research》 |2012年第10期|1748-1766|共19页
作者
Paola Maccioni; Alessandro Zaru; Barbara Loi; Carla Lobina; Mauro A. M. Carai; Gian Luigi Gessa; Alessandro Capra; Claudia Mugnaini; Serena Pasquini; Federico Corelli; Petri Hyyti; Lawrence Lumeng; Giancarlo Colombo;
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作者单位

Section of Cagliari Neuroscience Institute National Research Council of Italy Monserrato Italy;

Department of Life and Environmental Sciences University of Cagliari Cagliari Italy;

Department of Pharmaceutical and Applied Chemistry University of Siena Siena Italy;

Institute of Biomedicine/Pharmacology University of Helsinki Helsinki Finland;

Department of Medicine Indiana University Indianapolis Indiana;

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正文语种 eng
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关键词
GABAsubB/sub Receptor Agonist Baclofen; Positive Allosteric Modulator of the GABAsubB/sub Receptor GS39783; Operant Oral Alcohol Self-Administration; Reinforcing and Motivational Properties of Alcohol; Alcohol-Preferring P Rats; Alcohol-Preferring sP Rats; Alcohol-Preferring A Rats;

机译：GABA sub B / sub受体激动剂巴氯芬;GABA sub B / sub受体GS39783的正变构调节剂;口服酒精的自我给药;酒精的增强和动机特性;偏爱酒精的P大鼠;酒精偏爱的sP大鼠;酒精偏爱的a大鼠;

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1. Comparison of the Effect of the GABA B Receptor Agonist, Baclofen, and the Positive Allosteric Modulator of the GABA B Receptor, GS39783, on Alcohol Self-Administration in 3 Different Lines of Alcohol-Preferring Rats [J] . MaccioniP., ZaruA., LoiB., Alcoholism: Clinical and experimental research . 2012,第10期

机译：比较GABA B受体激动剂巴氯芬和GABA B受体正变构调节剂GS39783对三种不同品系的嗜酒精大鼠的酒精自我给药的影响
2. Reducing effect of the positive allosteric modulator of the GABAB receptor, GS39783, on alcohol self-administration in alcohol-preferring rats [J] . Paola Maccioni, Daniela Pes, Alessandro Orrù, Psychopharmacology . 2007,第2期

机译：GABAB 受体正变构调节剂GS39783降低偏好酒精的大鼠自我饮酒的作用
3. Specific reduction of alcohol's motivational properties by the positive allosteric modulator of the GABAB receptor, GS39783--comparison with the effect of the GABAB receptor direct agonist, baclofen. [J] . Maccioni P, Fantini N, Froestl W, Alcoholism: Clinical and experimental research . 2008,第9期

机译：通过GABAB受体的正构构调节剂GS39783特异性降低了酒精的动机特性，与GABAB受体直接激动剂巴氯芬的作用相比。
4. An efficient and rational method for selecting allosteric modulators to GABAA receptors using ligand-directed chemistry [C] . Kei Yamaura, Shigeki Kiyonaka, Seiji Sakamoto 日本化学会春季年会講演予稿集 . 2018

机译：用配体导化学选择颠覆调节剂对GABAA受体的高效合理方法
5. Development of lentiviral vector mediated gene delivery techniques and stable cell lines for investigating the action of ethanol and other allosteric modulators of glycine and GABAA receptors. [D] . Modi, Dimple Ashok. 2011

机译：慢病毒载体介导的基因传递技术和稳定细胞系的开发，用于研究乙醇和甘氨酸和GABAA受体的其他变构调节剂的作用。
6. Comparison of the effect of the GABAB receptor agonist baclofen and the positive allosteric modulator of the GABAB receptor GS39783 on alcohol self-administration in three different lines of alcohol-preferring rats [O] . Paola Maccioni, Alessandro Zaru, Barbara Loi, -1

机译：Gabab受体激动剂Babab受体GS39783的阳性变构调节剂对三种不同醇偏爱大鼠酒精自我施用的影响的比较
7. Comparison of the effect of the positive allosteric modulator of the GABAb receptor, GS39783, on alcohol self-administration in three different lines of alcohol-preferring rats [O] . Maccioni, P., Zaru, A., Loi, B., 2012

机译：比较GaBab受体阳性变构调节剂Gs39783对3种不同系列酒精偏好大鼠酒精自我给药的影响

Comparison of the Effect of the GABAB Receptor Agonist, Baclofen, and the Positive Allosteric Modulator of the GABAB Receptor, GS39783, on Alcohol Self-Administration in 3 Different Lines of Alcohol-Preferring Rats

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Comparison of the Effect of the GABA_B Receptor Agonist, Baclofen, and the Positive Allosteric Modulator of the GABA_B Receptor, GS39783, on Alcohol Self-Administration in 3 Different Lines of Alcohol-Preferring Rats