USE OF THE GABAB RECEPTOR IN ASSAYS TO IDENTIFY GAMMA HYDROXYBUTYRATE AGONISTS, ANTAGONISTS, AND ALLOSTERIC MODULATORS OF AGONISTS

摘要

An unexpected and novel mechanism of action for gamma hydroxybutyrate (GHB) has been discovered: agonist activity at the functional GABAB receptor. The discovery of this mechanism of action allows for the development of assays for the identification of modulators, such as agonists and antagonists, of GHB.