Development of highly-integrated plastic biochips; Open the doorway to low-cost and desk-side medical diagnosis

摘要

Replica biochips for capillary array electrophoresis with 10 separation channels (50 μm width, 50 μm depth and 100 μm pitch) were successfully fabricated on a poly(methyl methacrylate) (PMMA) substrate using injection molding technique. The current fabrication method used moving mask deep X-ray lithography to fabricate an array of channels with inclined channel sidewalls. A slight inclination of channel sidewalls is highly required to ensure the release of replicated biochips from a mold.