A DNA Nanostructure-based Biomolecular Probe Carrier Platform for Electrochemical Biosensing

摘要

A critical challenge in surface-based biomolecular detection is the reduced accessibility of target molecules to probes arranged on a heterogeneous surface compared to probe-target recognition in homogeneous solution. To improve the recognition abilities of such heterogeneous surface probes, much effort has been devoted to control the surface chemistry, conformation, and packing density of the probe molecules as well as the size and geometry of the surface. Here, we devise a new concept to achieve improved probe-target recognition properties by introducing a probe bearing a 3D DNA nanostructure-based chip platform.