Mammalian wound healing, an evolutionary process linked to plant’s response to stress: another proof toward unified healing mechanisms

摘要

Wound healing is a complex reparative process not restricted to humans. This unique process is observed in each wounded living organism which re-sets its own developed healing programs. The gross appearance of the healed wounds vary, but the underlying mechanisms pass through a unified single common path known as “response to stress”. Stressors are internal or external factors with devastative influence on a tissue which lead to cell damage and consequently give rise to a series of efficient spatial and temporal defensive events to neutralize them. Response to stressors comprises changes in cell cycle and division, cell membranes, cell wall architecture and metabolism. In plants wound healing process is through based on the response to stress. The same events are observed in human wound responses. Knowledge about the similarities and dissimilarities in the healing process between various organisms help us provide therapeutic strategies based on the clarified weak and strong points. Thus, in this article the similar wound responses in plants and human are described and compared.