Effect of captopril on platelet cytosolic[Ca~2+]_i and plasma TXA_2/PGI_2 in renovascular hypertensive rats

摘要

Conclusion: The altered TXA_2/PGI_2 after Cap treatment contributed to the improvement of the platelet[Ca~2+]_i and Pag. Aim: To study the effect of captopril(Cap)on Plately cytosolic free calcium concentration ([Ca~2+]_i), platelet aggregation(PAg), and plasma TXA_2/PGI_2 ratio in the renovascular hypertensive rats. Methods: blood pressure was measured once a Week by tail-cuff microphonic manometer. Platelet [Ca~2+]_i was measured by Fura -AM. Plasma angiotensinⅡ(Ang), thromboxane A_2(TXA_2), and prostacycline(PGI_2)were measured by radio- immunoassay.