Effects of nitroquine on ultrastructure and cytochrome oxidase of exoerythrocytic Plasmodium yoelii in rat liver

摘要

Conclusion: CCO was not the starting point of NA action. NA interferes with the structure and function of the cytoplasm and nucleus of malaria parasites and exerts its antimalarial effects in many aspects. Aim: To study the effects of nitroquine acetate (NA)on the ultrastructures and cytochrome-c oxidase(CCO)of exoerythrocytic forms(EEF)of Plasmodium yoelii. Methods: Rats were Inoculated with sporozoites directly into the liver. After 48 h rats were killed. Rat liver thin Sections were incubated in histochemical reaction Medium, then examined by transmission electron Microscopy.