Pharmacokinetics of sustained-release capsule of 5-isosorbide mononitrate in 20 healthy Chinese young men

摘要

AIM: To compare the pharmacokinetics of domestic and imported sustained-release capsule of 5-isosorbide mononitrate (5-IM). METHODS: A single and 5-d- repeated oral doses of 5-IM 50 mg were performed on 2 groups of 20 Chinese healthy subjects (10 subjects for each group) in a randomized crossover protocol. CONCLUSION: Domestic 5-IM sustained-release Capsule showed bioequivalence compared with the Imported capsule and provided the same nitrate-low Interval in the latter part of the 24-h dosing interval.