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首页> 外文期刊>Acta Pharmacologica Sinica >Intraventricular vascular endothelial growth factor antibody increases infarct volume following transient cerebral ischemia
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Intraventricular vascular endothelial growth factor antibody increases infarct volume following transient cerebral ischemia

机译:短暂性脑缺血后脑室内血管内皮生长因子抗体增加梗死体积

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摘要

AIM: To clarifyb the role of vascular endothelial growth factor (VEGF) in neuronal damage induce by cerebral ischemia. METHODS: Expression of VEGF in adult rat brain was measured by Immunohistochemistry. Transient middle cerebral Artery occlusion (MCA) model was induced by Placing a nylon thread in the lumen of the internal Carotid artery. The infarct volume was shown with 2,3,5-triphenyltetrazolium chloride (TTC) staining and quantitated by computer image analyzer with and without VEGF antibody treatment.
机译:目的:阐明血管内皮生长因子(VEGF)在脑缺血引起的神经元损伤中的作用。方法:采用免疫组织化学方法检测成年大鼠脑中VEGF的表达。通过在颈内动脉腔内放置尼龙线,诱发短暂的大脑中动脉阻塞(MCA)模型。用2,3,5-三苯基四唑氯化物(TTC)染色显示梗塞体积,并通过计算机图像分析仪定量分析有无VEGF抗体治疗。

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