Population pharmacokinetic analysis of amikacin and validation on neonates using Monte Carlo method

摘要

The stability of our self-made pro- gram was good. The population parameters obtained from this approach were in conformity with those from 2p87, and the interindividual variability was relatively small. The estimation program of population parameter And individual parameter made by us ran stably, and al- Lowed us to use sparse data to estimate population phar- Macokinetic parameters. In provided accurate estimates Of these parameters and satisfactory ability of serum con- Centration prediction. Therefore, it can be used for the Population pharmacokinetic analysis and individualization Of dosage regimen.