Moclobemide-induced gynecomastia in rats

摘要

After 180-d mo- clobemide treatment, the presence of gynecomastia was 0, 5, 5, 7/10 rats in 0, 60, 24, and 600 mg/kg groups, respectively. After 30-d convalescence, only one rat in 600 mg/kg group got the incidence of gyneco- mastia. Long-term treatment with moclobemide cause gyneco- Mastia in rats, which is reversible. The mechanism of Moclobemide-induced gynecomastia may be related to the Increase in prolactin receptors in mammary glands.