Effects of salvianolic acid-A on rat hepatic stellate cell proliferation and collagen production in culture

摘要

SA-A 100 μmol/L showed a little cytotoxity, SA-A 0.1-10μmol/L did not influence cell morphology, and SA-A 1-100μmol/ L decreased the cell proliferation significantly in a con- Centration-dependent manner(P < 0.05). SA-A 1, 10, 100μmol/L decreased the cell collagen deposition by 78.6/100, 71.8/100, and 61.3/100 of the control respec- tively (P < 0.05), and decreased type I collagen secre- tio to 53.1/100, 52.6/100, and 49.5/100(P < 0.01 or P < 0.05). SA-A inhibited HSC prolifer- Ation and collagen expression. The inhibitory effect on HSC activation is the main mechanism of SA-A action a- Gainst liver fibrosis.